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KMID : 1005420120140020084
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Journal of Cerebrovascular and Endovascular Neurosurgery
2012 Volume.14 No. 2 p.84 ~ p.89
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Effectiveness of Nicardipine for Blood Pressure Control in Patients with Subarachnoid Hemorrhage
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Kim Sang-Yong
Kim Seong-Min
Park Moon-Sun
Kim Han-Kyu
Park Ki-Seok
Chung Seong-Young
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Abstract
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Objective: The purpose of the study is to determine the effectiveness and safety of nicardipine infusion for controlling blood pressure in patients with subarachnoid hemorrhage (SAH).
Methods: We prospectively evaluated 52patients with SAH and treated with nicardipine infusion for blood pressure control in a 29months period. The mean blood pressure of pre-injection, bolus injection and continuous injection period were compared. This study evaluated the effectiveness of nicardipine for each Fisher grade, for different dose of continuous nicardipine infusion, and for the subgroups of systolic blood pressure.
Results: The blood pressure measurement showed that the mean systolic blood pressure / diastolic blood pressure (SBP/DBP) in continuous injection period (120.9/63.0mmHg) was significantly lower than pre-injection period (145.6/80.3mmHg) and bolus injection period (134.2/71.3mmHg), and these were statistically significant (p<0.001). In each subgroups of Fisher grade and different dose, SBP/DBP also decreased after the use of nicardipine. These were statistically significant (p<0.05), but there was no significant difference in effectiveness between subgroups (p>0.05). Furthermore, controlling blood pressure was more effective when injecting higher dose of nicardipine in higher SBP group rather than injecting lower dose in lower SBP group, and it also was statistically significant (p<0.05). During the infusion, hypotension and cardiogenic problems were transiently combined in five cases. However, patients recovered without any complications.
Conclusion: Nicardipine is an effective and safe agent for controlling acutely elevated blood pressure after SAH. A more systemic study with larger patients population will provide significant results and will bring solid evidence on effectiveness of nicardipine in SAH.
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KEYWORD
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Nicardipine, Hypertension, Subarachnoid hemorrhage, Aneurysm
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